IBUPROFEN SYRUP 100ML

Overview & Mechanism of Action

• Ibuprofen Syrup ($100\text{ml}$ bottle of $100\text{mg}/5\text{ml}$ oral suspension) delivers effective anti-inflammatory and antipyretic relief for infants and children:
• Reversible Cyclooxygenase ($\text{COX}$) Inhibition: Inactivates both $\text{COX-1}$ and $\text{COX-2}$ enzymes, blocking the peripheral synthesis of arachidonic acid into pro-inflammatory and pyrogenic prostaglandins ($\text{PGE}_2$).
• Hypothalamic Thermoregulation (Antipyresis): Suppresses elevated $\text{PGE}_2$ concentrations in the preoptic region of the anterior hypothalamus, resetting the central thermostat to lower fever and facilitate cutaneous heat dissipation.
• Peripheral Nociceptive Suppression: Reduces localized tissue edema and inflammatory sensitizing of peripheral pain receptors, relieving acute pediatric aches, teething pressure, and sore throat irritation.

Clinical Indications & Uses

• Ibuprofen Syrup 100ml is indicated for:
• Rapid reduction of elevated body temperature caused by viral or bacterial childhood infections, colds, and flu
• Relief of mild-to-moderate pediatric pain, including teething discomfort, toothaches, earaches, sore throats, and minor sprains
• Symptomatic management of post-immunization pyrexia and localized injection site pain

Usage Guidance & Safety Precautions

Administration:

• Shake bottle thoroughly before each dose. Use the provided calibrated oral dosing syringe or measuring cup to ensure accurate administration. Give during or immediately after a meal or milk feed to minimize stomach upset.

Recommended Dosage:

• Infants 3 to 6 months ($>5\text{kg}$): $2.5\text{ml}$ ($50\text{mg}$) up to 3 times in 24 hours.
• Infants 6 to 12 months: $2.5\text{ml}$ ($50\text{mg}$) 3 to 4 times in 24 hours.
• Children 1 to 3 years: $5\text{ml}$ ($100\text{mg}$) 3 times in 24 hours.
• Children 4 to 7 years: $7.5\text{ml}$ ($150\text{mg}$) 3 times in 24 hours.
• Children 8 to 12 years: $10\text{ml}$ ($200\text{mg}$) 3 times in 24 hours.
• Do not give to infants under 3 months or weighing under $5\text{kg}$ unless prescribed by a physician. Leave 6 to 8 hours between doses.

Precautions & Warnings:

• For pediatric oral administration. Do not exceed stated doses; unmonitored chronic use increases risks of gastrointestinal irritation and renal impairment. Avoid co-administering with other NSAIDs or aspirin. Use with caution in children with a history of asthma, severe dehydration, or chronic kidney/liver dysfunction. Store below $25^\circ\text{C}$ in a cool, dry place. Keep out of reach of children.