KETO-PLUS SHAMPOO 120ML

Overview & Mechanism of Action

• Keto-Plus Shampoo ($120\text{ml}$ bottle) provides targeted antifungal and cytostatic therapy engineered to treat persistent inflammatory scalp conditions:
• Targeted Ergosterol Inhibition (Ketoconazole $2\%$): Potent imidazole antifungal that inhibits fungal cytochrome P450-dependent $14\alpha$-demethylase. This blocks the synthesis of ergosterol in fungal cell membranes, leading to membrane lysis and total clearance of Malassezia (Pityrosporum) yeast species linked to seborrheic dermatitis.
• Epidermal Normalization (Zinc Pyrithione $1\%$): Exhibits broad antimicrobial activity while regulating epidermal turnover rate. It normalizes keratinization in hyperproliferative epidermal layers, reducing excessive shedding of dead skin scales.
• Rapid Anti-Pruritic Action: Rapidly alleviates localized scalp redness, inflammation, and intense itching while maintaining scalp moisture and protecting hair follicle structure.

Clinical Indications & Uses

• Keto-Plus Shampoo 120ml is indicated for:
• Treatment and prevention of moderate-to-severe seborrheic dermatitis of the scalp and hair-bearing areas
• Eradication of severe, persistent dandruff (pityriasis capitis) characterized by thick, oily flakes and scaling
• Adjunctive management of localized cutaneous pityriasis versicolor (tinea versicolor) on scalp and neck areas

Usage Guidance & Safety Precautions

Administration:

• Wet hair and scalp thoroughly with warm water. Apply an adequate amount of shampoo to produce a rich lather, gently massaging into the scalp with fingertips. Leave on the scalp for 3 to 5 minutes before rinsing thoroughly with clean water.

Recommended Dosage:

• Active Treatment: Use 2 times weekly for 2 to 4 consecutive weeks.Maintenance: Use once every 1 to 2 weeks to prevent recurrence of flakes and itching.

Precautions & Warnings:

• For external topical scalp application only. Avoid direct contact with eyes; if accidental exposure occurs, flush eyes immediately with generous amounts of water. May cause minor irritation or mild hair color discolouration in chemically bleached or permed hair. Discontinue use if localized allergic skin irritation develops. Store below $25^\circ\text{C}$ in a cool, dry place protected from direct heat and light. Keep out of reach of children