Nicorette 4Mg Freshfruit 30S

Overview & Mechanism of Action

• Nicorette 4mg Freshfruit Chewing Gum (30 pieces per box) delivers controlled buccal nicotine release designed to substitute the systemic nicotine derived from tobacco combustion:
• Buccal Transmucosal Absorption (Nicotine Polacrilex): As the gum is chewed using the "chew and park" technique, bound nicotine is liberated from the ion-exchange resin matrix and absorbed directly through the oral buccal mucosa into systemic circulation, bypassing hepatic first-pass metabolism.
• Central Nicotinic Receptor Activation: Systemically absorbed nicotine binds to central mesolimbic nicotinic acetylcholine receptors, inducing dopamine release to satisfy tobacco cravings and alleviate irritability, anxiety, and restlessness associated with acute nicotine withdrawal.
• Dose-Regulated Harm Reduction: Provides a clean, controlled dose of therapeutic nicotine without exposing pulmonary tissue to harmful tars, carbon monoxide, or toxic combustion carcinogens found in cigarette smoke.

Clinical Indications

• Nicorette 4mg Freshfruit 30s is indicated for:
• Smoking cessation and temporary reduction of tobacco consumption in heavy smokers (individuals who smoke more than 20 cigarettes per day or smoke their first cigarette within 30 minutes of waking)
• Relief of acute nicotine cravings and physical withdrawal symptoms during complete smoking cessation attempts
• Combination NRT regimens (under medical guidance) alongside transdermal nicotine patches for breakthrough craving control

Usage Guidance & Safety Precautions

Administration ("Chew and Park" Method):

• Chew 1 piece slowly until a distinct, spicy fruit flavor or tingling sensation is felt in the mouth. Then "park" the gum between your cheek and gums. When the taste fades, chew slowly again until the tingle returns, then park in a different spot. Repeat this cycle for approximately 30 minutes until the gum is spent.

Recommended Dosage:

• High Dependence Smokers: Chew 1 piece of 4mg gum every 1 to 2 hours as needed. Do not exceed 15 pieces of 4mg gum per day.
• Treatment Duration: Use continuously for up to 12 weeks, gradually reducing daily gum consumption over time before discontinuing completely.'

Precautions & Warnings:

• For buccal oral use only; do not swallow pieces whole. Avoid drinking acidic beverages (such as coffee, fruit juices, or soft drinks) 15 minutes before or during chewing, as acidic pH impairs buccal nicotine absorption. Contraindicated in non-smokers, children, and individuals with recent myocardial infarction, severe cardiac arrhythmias, unstable angina, or acute stroke. Exercise caution in patients with active peptic ulcer disease, uncontrolled hyperthyroidism, or severe hypertension. Store in a cool, dry place. Keep strictly out of reach of children and pets.