Physiogel Calming Relief A.I Cream 50g

Overview & Mechanism of Action

• Physiogel Calming Relief A.I. Cream ($50\text{g}$ tube formulated with high-concentration Palmitoylethanolamide $\text{PEA}$ and essential structural lipids) offers rich, concentrated barrier repair and neuro-calming action for targeted or facial application:
• Endogenous Anti-Itch & Anti-Inflammatory Signaling ($\text{PEA}$ Action): Contains Palmitoylethanolamide ($\text{PEA}$), an endogenous fatty acid amide that modulates cutaneous sensory nerve activity and stabilizes mast cells. $\text{PEA}$ inhibits localized mediator release, rapidly blunting acute itch responses and diminishing visible facial or localized erythema.
• Concentrated BioMimic Lipid Matrix: Features a dense lamellar derma-membrane structure that replicates the natural lipid architecture of healthy stratum corneum. It delivers concentrated ceramides, squalane, and hydrogenated lecithin deep into hyper-reactive or broken epidermal layers.
• Intensive Occlusive Barrier Protection: Forms a rich, protective lipid shield over severely xerotic, cracked, or inflamed skin. This drastically reduces transepidermal water loss ($\text{TEWL}$), seals micro-fissures, and defends against environmental irritants and contact allergens.

Clinical Indications & Uses

• Physiogel Calming Relief A.I. Cream 50g is indicated for:
• Targeted emollient therapy for acute flare-ups of eczema, atopic dermatitis, and hyper-reactive skin on the face, hands, or localized body areas
• Rapid relief of intense localized itching, burning tightness, and skin redness associated with compromised barrier function
• Soothing hyper-sensitive skin exposed to harsh weather, chemical irritants, or dermatological treatments

Usage Guidance & Safety Precautions

Administration:

• Apply a small amount to clean, dry skin on affected facial or body areas twice daily, or as needed. Gently smooth over skin until absorbed.

Recommended Dosage:

• Adults, Children, and Infants: Apply twice daily (morning and evening) or as needed to localized dry, itchy patches.

Precautions & Warnings:

• For external dermatological use only. Avoid direct contact with eyes; if contact occurs, rinse thoroughly with clean water. Discontinue use if localized hypersensitivity or unexpected irritation develops. Hypoallergenic, non-comedogenic, and formulated without conventional emulsifiers, fragrances, colorants, or preservatives. Store below $25^\circ\text{C}$ in a cool, dry place away from direct heat and light. Keep out of reach of children.