UNIORTHO 500MG TABS 10S

Overview & Mechanism of Action

• Uniortho 500mg Tablets ($10\text{-tablet}$ blister pack containing Glucosamine Sulfate $500\text{mg}$) provides fundamental biochemical building blocks required for articular cartilage repair and joint lubrication:
• Glycosaminoglycan & Proteoglycan Synthesis: Serves as a primary substrate for the endogenous biosynthesis of glycosaminoglycans (GAGs), proteoglycans, and hyaluronic acid within the extracellular matrix of articular cartilage, promoting structural matrix restoration.
• Chondroprotective & Anti-Catabolic Activity: Inhibits catabolic enzymes such as collagenase, phospholipase A2, and aggrecanases while blunting nuclear factor kappa B ($\text{NF-}\kappa\text{B}$) inflammatory signaling pathways, slowing matrix breakdown and protecting chondrocytes.
• Synovial Fluid Viscoelasticity Enhancement: Stimulates synoviocytes and chondrocytes to synthesize quality synovial fluid, restoring articular cushioning, reducing inter-articular friction, and easing movement-induced joint stiffness.

Clinical Indications & Uses

• Uniortho 500mg Tablets 10s is indicated for:
• Symptomatic relief and long-term dietary management of mild-to-moderate osteoarthritis affecting knee, hip, spinal, and small peripheral joints
• Reducing morning joint stiffness, crepitus, and movement-associated pain in degenerative joint disorders
• Supporting overall cartilage structural integrity, joint flexibility, and range of motion in active or aging individuals

Usage Guidance & Safety Precautions

Administration:

• Swallow tablets whole with a full glass of water, preferably during or immediately after meals to minimize potential mild gastrointestinal discomfort.

Recommended Dosage:

• Adults: Take 1 tablet ($500\text{mg}$) 3 times daily (totaling $1,500\text{mg}$ daily) or as prescribed by an orthopedic physician. Consistent daily administration for 4 to 12 weeks is recommended to achieve optimal therapeutic benefits.

Precautions & Warnings:

• For oral administration. Use with caution in individuals with known shellfish or crustacean allergies, as glucosamine is commonly derived from marine exoskeletons. Diabetic patients should monitor blood glucose levels regularly during initiation, as glucosamine may theoretically influence insulin sensitivity. Consult a doctor prior to co-administration with oral anticoagulants (e.g., warfarin), as glucosamine may potentiate anticoagulant effects. Store below $25^\circ\text{C}$ in a cool, dry place away from heat and moisture. Keep out of reach of children.