URISOL CRANBERRY SATCHETS 10S

Overview & Mechanism of Action

• Urisol Cranberry Sachets ($10\text{-sachet}$ box containing concentrated Cranberry Extract and D-Mannose soluble powder) provides natural dual-action anti-adhesion protection across the urothelium:
• Uroepithelial Anti-Adhesion (PACs Action): High concentrations of Type-A Proanthocyanidins ($\text{PACs}$) selectively bind to the P-fimbriae (hair-like projections) of uropathogenic Escherichia coli ($\text{UPEC}$). This prevents the bacteria from anchoring onto the uroepithelial cell lining of the bladder and ureters.
• Competitive Lectin Blockade (D-Mannose Action): D-Mannose acts as a competitive inhibitor for Type-1 fimbriae on E. coli, forming a soluble complex that remains suspended in urine and is naturally flushed out during normal micturition.
• Urinary Environment Stabilization: Organic acids present within cranberry extract help maintain a healthy, balanced urinary $\text{pH}$ and reduce unpleasant urinary odors without disturbing beneficial systemic flora.

Clinical Indications & Uses

• Urisol Cranberry Sachets 10s is indicated for:
• Prophylaxis and nutritional management against recurrent uncomplicated lower urinary tract infections (cystitis)
• Adjunctive dietary support alongside antibacterial therapy during active urinary tract infections to accelerate microbial flushing
• Alleviating minor urinary irritation, cloudiness, burning sensations, and bladder discomfort

Usage Guidance & Safety Precautions

Administration:

• Dissolve the contents of 1 sachet in a glass of water ($150\text{ml}$ to $200\text{ml}$), stir well, and drink immediately. Maintain a daily fluid intake of 2 to 3 liters of water to promote thorough urinary tract rinsing.

Recommended Dosage:

• Adults and Children 12 years and older: Take 1 to 2 sachets daily dissolved in water, or as directed by a healthcare professional.

Precautions & Warnings:

• For oral administration after dissolution. Not a substitute for prescription antibiotic therapy in acute, complicated, or upper urinary tract infections (e.g., pyelonephritis). Seek immediate medical evaluation if fever, lower back pain, chills, or hematuria (blood in urine) occurs. Use with caution in patients with a history of calcium oxalate renal calculi (due to dietary oxalate content in concentrated cranberry extracts) or those taking Vitamin K antagonists (e.g., Warfarin). Store below $25^\circ\text{C}$ in a cool, dry place away from direct sunlight. Keep out of reach of children.