UROFIT SATCHETS 5G 6S

Overview & Mechanism of Action

• Urofit Sachets ($5\text{g}$ dissolvable oral powder, 6-sachet pack) provides targeted systemic and renal biochemical buffering to adjust urinary $\text{pH}$ and enhance crystalloid solubility:
• Urinary Alkalization & $\text{pH}$ Elevation: Systemic metabolism of citrate salts generates bicarbonate ions, raising urinary $\text{pH}$ into an optimal neutral-to-alkaline range ($6.5\text{ to } 7.2$). Elevating urinary $\text{pH}$ increases the solubility of uric acid, helping dissolve existing uric acid gravel and preventing new stone formation.
• Inhibition of Calcium Oxalate Crystallization: Citrate ions chelate with urinary calcium, reducing free ionic calcium saturation. This directly inhibits the nucleation, growth, and aggregation of calcium oxalate and calcium phosphate crystals in the renal tubules.
• Dysuria Relief: Neutralizes overly acidic urine passing over inflamed urothelial tissues, rapidly alleviating painful burning, frequency, and urethral irritation secondary to cystitis or hyperuricemia.

Clinical Indications & Uses

• Urofit Sachets 5g 6s is indicated for:
• Prophylaxis and dissolution of renal calculi (uric acid stones, calcium oxalate stones, and cystine lithiasis)Urinary alkalization for patients experiencing hyperuricemia, gouty nephropathy, or uricosuric therapy
• Symptomatic relief of burning micturition and dysuria associated with lower urinary tract irritation and mild cystitis

Usage Guidance & Safety Precautions

Administration:

• Dissolve the contents of 1 sachet ($5\text{g}$) completely in a glass of cool water ($150\text{ml}$ to $200\text{ml}$) and drink immediately after meals to reduce stomach discomfort. Maintain generous overall daily fluid intake to aid renal clearance.

Recommended Dosage:

• Adults: Take 1 sachet 2 to 3 times daily, or as individually prescribed by a urologist based on target urinary $\text{pH}$ monitoring.

Precautions & Warnings:

• For oral administration only. Contraindicated in patients with severe renal impairment, hyperkalemia, sodium-restricted conditions, uncompensated cardiac failure, or active urinary infections caused by urea-splitting bacteria. Use with caution in patients taking potassium-sparing diuretics, $\text{ACE}$ inhibitors, or cardiac glycosides. Store below $25^\circ\text{C}$ in a cool, dry place protected from humidity and heat. Keep out of reach of children.