VITAMIN D3 & K2 VCAPS 90S (VIR)

Overview & Mechanism of Action

• Vitamin D3 & K2 VCaps ($90\text{-capsule}$ bottle engineered with plant-based vegetarian capsules) provides dual-action micronutrient synergy to direct systemic calcium homeostasis safely:
• Intestinal Calcium & Phosphate Reabsorption (Vitamin D3): Active Cholecalciferol converts to $25\text{-hydroxyvitamin D}_3$ and subsequently to $1,25\text{-dihydroxyvitamin D}_3$ ($\text{Calcitriol}$), which upregulates intestinal expression of calcium-binding proteins (calbindins). This dramatically increases luminal absorption of dietary calcium ($Ca^{2+}$) and inorganic phosphate ($PO_4^{3-}$).
• Targeted Bone Matrix Mineralization (Vitamin K2 / MK-7): Menaquinone-7 ($\text{MK-7}$) acts as an essential cofactor for $\gamma$-glutamyl carboxylase, inducing post-translational carboxylation of osteocalcin. Carboxylated osteocalcin binds free circulating calcium ions, depositing them directly into the hydroxyapatite bone matrix.
• Vascular & Soft Tissue Anti-Calcification: Simultaneously carboxylates Matrix Gla Protein ($\text{MGP}$) in vascular smooth muscle and arterial walls. Active $\text{MGP}$ inhibits ectopic calcium deposition in arterial walls, preventing arterial stiffness and cardiovascular calcification.

Clinical Indications & Uses

• Vitamin D3 & K2 VCaps 90s is indicated for:
• Prophylaxis and supportive management of osteopenia, osteoporosis, and age-related bone mineral density loss
• Optimizing therapeutic outcomes during high-dose calcium or vitamin D supplementation by preventing soft tissue and arterial calcification
• Supporting healthy immune response regulation, muscle strength, and cardiovascular endothelial function

Usage Guidance & Safety Precautions

Administration:

• Swallow 1 capsule daily with food containing healthy fats (such as avocado, olive oil, or nuts) to maximize gastrointestinal absorption of these fat-soluble vitamins.

Recommended Dosage:

• Adults: Take 1 capsule daily, or as directed by a healthcare practitioner.

Precautions & Warnings:

• For oral consumption only. Contraindicated or requires mandatory medical supervision in patients taking vitamin K antagonist anticoagulants (such as Warfarin/Coumadin), as Vitamin K2 directly opposes the anticoagulant mechanism of coumarins. Patients with hypercalcemia, hyperparathyroidism, or sarcoidosis should consult a physician prior to use. Store below $25^\circ\text{C}$ in a cool, dry place protected from moisture and direct sunlight. Keep out of reach of children.