ATRIZIN SYRUP 5MG/5ML 60ML (CETRIZINE)

Overview & Mechanism of Action

• Atrizin Syrup (60ml bottle) delivers long-lasting symptom control for upper respiratory and dermatological allergic conditions:
• Selective Histamine $H_1$-Receptor Antagonism (Cetirizine HCl 5mg/5ml): Competitively blocks peripheral $H_1$ histamine receptors on target tissues, preventing endogenous histamine binding. This stops the allergic inflammatory cascade, reducing vascular permeability, mucosal edema, and sensory nerve itching.
• Inhibition of Eosinophil Migration: Suppresses the late-phase recruitment and migration of eosinophils and inflammatory mediators to affected cutaneous and mucosal tissues, preventing recurring allergy flare-ups.
• Low Central Nervous System Penetration: As a second-generation antihistamine, it exhibits minimal blood-brain barrier passage, providing continuous 24-hour allergy suppression with significantly reduced sedating effects compared to first-generation antihistamines.

Clinical Indications

• Atrizin Syrup 60ml is indicated for:
• Relief of seasonal allergic rhinitis (hay fever) and perennial allergic rhinitis, including sneezing, nasal itching, rhinorrhea (runny nose), and post-nasal drip
• Symptomatic treatment of ocular allergic manifestations such as itching, redness, and watery eyes (allergic conjunctivitis)
• Management of chronic idiopathic urticaria, soothing persistent skin itching, red wheals, and localized hives

Usage Guidance & Safety Precautions

Administration:

• Take orally using a precise measuring spoon or dosing syringe. May be taken with or without food.

Recommended Dosage:

• Adults & Children over 12 years: 10ml (10mg) once daily.
• Children 6 to 12 years: 5ml (5mg) twice daily or 10ml (10mg) once daily.
• Children 2 to 6 years: 2.5ml (2.5mg) twice daily or 5ml (5mg) once daily.
• Children under 2 years: Strictly as directed by a pediatrician.

Precautions & Warnings:

• Use with caution in patients with moderate-to-severe renal impairment or hepatic insufficiency (dose adjustment may be necessary). Although considered non-sedating, somnolence can occur in sensitive individuals; monitor response before driving or operating machinery. Avoid concurrent alcohol or central nervous system depressant consumption. Store below 25°C in a dry place protected from direct light and heat. Keep out of reach of children.