FRAMECAL TABLETS 30S (CAL CITRATE/MG/ZNC/VIT D3)

Overview & Mechanism of Action

• Framecal Tablets (30-tablet pack) delivers a synergistic bioavailable micronutrient matrix engineered to optimize bone mineralization and structural integrity:
• High-Absorption Organic Calcium (Calcium Citrate): Provides elemental calcium in a highly soluble organic citrate salt form that does not require stomach acid for dissolution or absorption. It integrates into the hydroxyapatite matrix of human bone, maintaining systemic calcium homeostasis and bone mass.
• Intestinal Calcium Absorption & Bone Remodeling (Vitamin D3 / Cholecalciferol): Facilitates active transcellular transport and absorption of dietary calcium and phosphorus across the intestinal mucosa. Vitamin D3 stimulates osteoblast function while maintaining optimal serum mineral concentrations for proper bone mineralization.
• Bone Matrix Integrity & Muscle Function (Magnesium): Serves as an essential mineral cofactor in parathyroid hormone (PTH) secretion and activation of Vitamin D to its active form ($1,25\text{-(OH)}_2\text{D}_3$). Magnesium regulates calcium deposition in bones while preventing ectopic arterial calcification and supporting neuromuscular function.
• Osteoblastic Enzymatic Support (Zinc): Functions as a essential cofactor for alkaline phosphatase, an enzyme critical for osteoblast activity and collagen synthesis within the bone extracellular matrix.

Clinical Indications

• Framecal Tablets 30s is indicated for:
• Prevention and adjunctive management of osteoporosis, osteopenia, and age-related bone density loss
• Nutritional supplementation during pregnancy, post-menopause, lactation, and advanced age when calcium demands are elevated
• Accelerating bone healing during fracture recovery and preventing calcium/Vitamin D deficiency states

Usage Guidance & Safety Precautions

Administration:

• Swallow 1 tablet whole with a glass of water, preferably with or immediately after a main meal. Do not chew, break, or crush the tablet.

Recommended Dosage:

• Adults & Adolescents (12 years and older): Take 1 tablet once or twice daily, or strictly as directed by a healthcare professional.

Precautions & Warnings:

• Use with caution in patients with hypercalcemia, hypercalciuria, nephrolithiasis (kidney stones), or severe renal impairment. Separate administration by at least 2 hours from bisphosphonates, fluoroquinolones, tetracyclines, or thyroid hormone treatments, as calcium decreases their intestinal absorption. Store below $25^\circ\text{C}$ in a dry place protected from direct light, heat, and moisture. Keep out of reach of children.