UNIEXTRA TABS 30S

Overview & Mechanism of Action

• Uniextra Tablets ($30\text{-tablet}$ pack containing Paracetamol $500\text{mg}$ and Caffeine $65\text{mg}$ per tablet) provides dual-action analgesic amplification for rapid pain control:
• Central Analgesic & Antipyretic Action (Paracetamol): Inhibits central nervous system prostaglandin synthesis via cyclooxygenase ($\text{COX}$) enzyme inhibition and modulates central serotonergic pathways to elevate the pain perception threshold and lower elevated body temperature at the hypothalamic thermoregulatory center.
• Analgesic Adjuvant & Vascular Action (Caffeine): Acts as a competitive antagonist at central adenosine receptors ($\text{A}_1$ and $\text{A}_{2\text{A}}$), inducing mild cerebral vasoconstriction to relieve throbbing vascular headaches and migraines. Furthermore, caffeine enhances the gastrointestinal absorption rate and biological efficiency of paracetamol, boosting overall analgesic potency.
• Rapid Onset & Extended Comfort: Engineered to provide fast-acting, enhanced relief for acute pain that does not respond adequately to single-ingredient paracetamol alone.

Clinical Indications & Uses

• Uniextra Tablets 30s is indicated for:
• Fast relief of acute mild-to-moderate pain, including tension headaches, vascular migraines, and sinus pressure pain
• Relief of musculoskeletal pain, backaches, rheumatic joint discomfort, and post-dental or toothache pain
• Symptomatic management of painful menstrual cramps (dysmenorrhea) and febrile body aches associated with viral infections, cold, or flu

Usage Guidance & Safety Precautions

Administration:

• Swallow tablets whole with water, with or without food.

Recommended Dosage:

• Adults and Children 12 years and older: Take 1 to 2 tablets every 4 to 6 hours as needed. Do not exceed 8 tablets ($4000\text{mg}$ paracetamol) in any 24-hour period.

Precautions & Warnings:

• For oral administration. Do not exceed the stated dose, as severe, irreversible liver damage may occur from paracetamol overdose. Avoid concurrent use with other paracetamol-containing products or excessive dietary caffeine (coffee, tea, energy drinks), which may cause nervous restlessness, insomnia, or heart palpitations. Contraindicated in individuals with severe hepatic impairment. Use with caution in severe renal insufficiency or chronic alcohol dependence. Store below $25^\circ\text{C}$ in a cool, dry place away from direct light. Keep out of reach of children.